shutterstock_469997516.jpg

WHAT IS CBD?

CBD is one of 85 chemical substances known as cannabinoids. CBD—is a chemical compound found in both Hemp and Cannabis plants. CBD is one of the most abundant cannabinoids in hemp and cannabis plants, but not the most famous. That notoriety belongs to Tetrahydrocannabinol (THC). THC is the only cannabinoid that causes psychoactivity, (getting high). 

 

WHERE DOES CBD COME FROM?

In addition to being naturally occurring in the human body, CBD can be extracted in oil form from specific varieties of hemp and cannabis plants. To be very clear CBD is not THC, CBD does not contain THC. CBD is non-psychoactive. This makes CBD an appealing option for athletes looking for relief without the unwanted effects of a psychoactive drug.

 

HOW CBD WORKS?

The main difference between CBD and its famous sister THC are the body’s receptors they stimulate. 

CBD activates receptors, like the vanilloid, adenosine and serotonin receptors. By activating the these receptors they can play a role in the mediation of body temperature, pain perception and inflammation

The activation of adenosine receptors by CBD gives the anti-anxiety and anti-inflammatory effects of cannabidiol. Adenosine receptors are also involved in the release of dopamine and glutamate, two neurotransmitters that play major roles inside the body. Dopamine is involved in cognition, motor control, motivation and reward mechanisms, while glutamate is one of the major mediators of excitatory signals, being involved in memory, learning and cognition.

High concentrations of CBD have been shown to activate the 5-HT1A serotonin receptor, exerting anti-depressant effects. The same receptor is involved in a series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms.

CBD blocks CPR55 signaling, decreasing bone re-absorption and cancer cell proliferation. GPR55 is widely present inside the brain, being linked with the modulation of bone density and blood pressure, as well as with cancer cell proliferation 

Uniquely CBD blocks the psychoactive action of THC, this being one of the reasons it’s generally considered advantageous to combine CBD and THC when for treatment purposes THC is required such as in conjunction with chemotherapy.

However, the positive effects of cannabidiol are not dependent on the presence of THC, so you can still take advantage of the health benefits of CBD by purchasing products that contain only non-psychoactive CBD

 

IS CBD LEGAL?

CBD products from “hemp” strains are legal in all 50 states.

 

WILL THIS PRODUCT BE DETECTED IN DRUG TESTS?

THC-free CBD would never register positive for drug use.

 

References

1.         Pertwee RG., Pharmacology of cannabinoid receptor ligands, Current medical chemistry, 1999, 6(8):635-64; http://www.ncbi.nlm.nih.gov/pubmed/10469884

2.         Ashton JC, Wright JL, McPartland JM, Tyndall JD, Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB-2 selective antagonists, Current medical chemistry, 2008, 15(14):1428-43; http://www.ncbi.nlm.nih.gov/pubmed/18537620

3.         http://en.wikipedia.org/wiki/Cannabinoid_receptor_type_1

4.         Racz I, Nadal X, Alferink J et al., Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain, The Journal of Neuroscience, 2008, 28(46):12125-35;   http://www.jneurosci.org/content/28/46/12125.long

5.         http://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2

6.         Costa B., Giagnoni G. et al., Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation, British Journal of Pharmacology, 2004, 143(2):247-50; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575333/